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Drugs by Condition SAMe might be an effective treatment for depression, with fewer side effects than antidepressant drugs. But the real benefits and risks of SAMe are still unclear. In theory, it may increase the risk of heart disease. People with depression or joint pain should seek medical advice before trying SAMe. Supplementation with SAM-e increases levels of serotonin, dopamine and phosphatides, and improves serotonin and dopamine receptor site binding. Some research has shown that SAM-e provides relief from arthritis pain, without the stomach irritation caused by aspirin and similar drugs.
Are there any side effects associated with SAMe supplementation?
Side Effects SAMe is a very safe dietary supplement. Minor side effects include nausea and gastrointestinal irritation, due to its sulfur content. These were only noted at very high doses (1200-1600mg) and symptoms diminished with continued use. Persons suffering from manic depression (bipolar disorder) should not take SAMe without prior consultation with their physician. If you experience any of the symptoms above for an extended period of time, you may be allergic to SAMe, or it may not be the right supplement for you.
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Dosage Benefits.
Pregnancy Warnings • treatment for depression.